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The most frequently used are theCierny–Mader classification [11] (Table 17.1) for long bone osteomyelitis, and thePerfusion, Extent, Depth, Infection, Sensation (PEDIS) classification for diabetic footosteomyelitis [12–14] (see Chapter 18). As cancerous cellsdivide and rapidly proliferate, they use up the available oxygen and, without aproper vasculature, many tumour regions become chronically hypoxic

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